Asian Journal of Research in Medical and Pharmaceutical Sciences 2021-09-10T02:52:45+00:00 Asian Journal of Research in Medical and Pharmaceutical Scie Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Medical and Pharmaceutical Sciences&nbsp;(ISSN: 2457-0745)</strong>&nbsp;aims to publish research papers, reviews and short communications in the areas of&nbsp;medical and pharmaceutical sciences. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. This journal will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. This journal is novelty attracting, open-minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Assessment of Health Risk of Daily Fluoride Intake of Some Selected Dentifrices used in Port Harcourt, Nigeria 2021-06-09T21:16:50+00:00 Kpalap, Pretty Tonubari Bartimaeus, Ebirien-Agana Samuel Brown, Holy <p><strong>Background: S</strong>everal dentifrices are marketed and used by individuals for the purposes of cleaning and maintaining the aesthetic and health of the teeth, promote oral hygiene and aid in removal of dental plaque and food materials from the teeth. This study was thus designed to assess the pH and fluoride concentrations in selected dentifrices and the possible health risks associated with daily fluoride intake of these selected dentifrices used in Port Harcourt, Nigeria.</p> <p><strong>Materials and Methods: </strong>This study estimated the pH and fluoride concentration of the different dentifrices by the pH meter and Ion Selective Electrode method. In addition, the Daily fluoride intake (DFI), Chronic daily intake (CDI) and Hazard quotient (HQ) for the different dentifrices to assess the risk of fluoride intake was calculated.</p> <p><strong>Results: </strong>From the result of this study, it was noticed that only one dentifrice, chewing stick (<em>Massularia acuminate</em>) has a pH (6.8) that conform to the recommended pH range (6.0-7.5) by NAFDAC while the other dentifrices have a pH value (7.6-10.1) that was higher than the pH range recommended by NAFDAC. For the fluoride concentration, it was observed that some of the dentifrices like Dr. Agnes Nwanmma dental powder (440 ppm), Dr. White dental powder (480 ppm) and Eradental powder (760 ppm) have low fluoride concentration when compared with the fluoride standard concentration stipulated by SON/ NAFDAC (825-1250 ppm) while the other dentifrices showed fluoride concentration within the range stipulated by stipulated by SON/ NAFDAC but they were below the fluoride concentrations stated on their different labels. The DFI of the dentifrices was within the range (53.86-131.58 mg/day), CDI (0.744-1.8275 mg/kg/day and the HQ (12.27-30.46).</p> <p><strong>Conclusion: </strong>Although the fluoride concentrations of the dentifrices were within the normal range as stipulated by NAFDAC and SON, the observation of HQ &gt; 1 in all the dentifrices implied that dentifrices commonly used in Nigeria may pose health risk to the consumers.</p> 2021-06-03T06:45:06+00:00 ##submission.copyrightStatement## Zero Prevalence of HIV and HCV Coinfection in the Highly HIV-infected Population of Rivers State, Nigeria 2021-09-10T02:52:45+00:00 Iheanyi O. Okonko Tochi I. Cookey Nnenna Frank-Peterside <p><strong>Background: </strong>Hepatitis C affects 5–15% of the 38 million people living with HIV globally. Africa which has the second highest prevalence of HIV/HCV co-infection following Asia. This alarming statistics has made it crucial that studies be done to also ascertain the HIV/HCV co-infection prevalence in the country and host factors which may influence the co-infection.</p> <p><strong>Objective: </strong>Therefore, this study was conducted to investigate the seroprevalence of HCV infection amongst the HIV population of Rivers state, Nigeria.</p> <p><strong>Study Design:</strong> Cross-sectional study.</p> <p><strong>Place and Duration of Study:</strong> University of Port Harcourt Teaching Hospital (UPTH), in Rivers State, Nigeria, from February 2017 to September 2019.</p> <p><strong>Methods: </strong>In this study, 226 HIV-infected individuals were recruited comprising 105 males and 121 females. These subjects were screened for the presence of HIV and HCV using ELISA and was performed according to the kit manufacturer’s stipulations. The demographic characteristics of the participants were obtained using a questionnaire designed for the study.</p> <p><strong>Results: </strong>The presence of antibodies to HIV-1 reconfirmed the HIV status in all the study subject. A seroprevalence rate of 0.0% was observed for HIV/HCV infection. The ratio of females to males was found to be 1.2:1. The ages of the study population ranged from 16 to 70 years with a median age of 42.5 years. A large number (30.5%, n = 69) of the participants were within the age group 40 – 49 years, followed by those within 30 – 39 years (26.1%, n= 59), 50 – 59 years (17.3%, n = 39) and &gt;59 years (13.7%, n = 31). Participants that were within younger age groups had less population; 20 – 29 years (9.7%, n = 22), with those that are &lt;20 years having the least population (2.7%, n = 6). Many (49.1%, n = 111) of the study participants were found to be married. About 46.5% (n = 105) of them were single, while a few (4%, n = 10) were widowed.</p> <p><strong>Conclusion: </strong>No coinfection of HIV/HCV was found, in spite of Nigeria being endemic for HCV. However, despite this zero rate of HIV/HCV coinfection, routine screening for HCV markers should be carried out to reduce morbidity and mortality in HIV-infected individuals.</p> 2021-09-07T00:00:00+00:00 ##submission.copyrightStatement##